Erowid Sertraline (Zoloft) Vault: Basics

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Sertraline (Zoloft) Basics
by Erowid

DESCRIPTION
Sertraline is an SSRI (Selective Serotonin Reuptake Inhibitor) which changes the body's regulation of serotonin by blocking the reuptake of serotonin into 5HT neurons. As with other SSRI's, Zoloft can take several weeks before it produces the desired effects.
[ Main Sertraline Vault ]

History
Sertraline was introduced in 1986 as a treatment for depression and obsessive compulsive disorder.

Slang
The Substance: Sertraline, Zoloft (Pfizer)

PROBLEMS

Possible Interactions

Alcohol and other depressants may increase the effects of sertraline and may depress respiration and blood pressure.

Anticonvulsants: sertraline may decrease the effectiveness of anticonvulsants and lower the seizure threshold.

Antihistamines: sertraline may increase the effects of antihistamines including side effects.

Digitalis: sertraline may increase the risk of sideeffects.

Lithium: sertraline could increase the levels of lithium in the blood leading to toxicity.

MAOIs (MonoAmine Oxidase Inihibitors): sertraline taken with MAOIs is extremely dangerous and can lead to severe or fatal reactions including very high blood pressure, seizures, tremors, coma, extreme headaches, nausea, among other unpleasant side effects.

Other Antidepressants: combining antidepressants will likely increase the side effects and increase the effects of the combined drugs.

Last Modified - Sat, Jan 19, 2008

Created by Erowid

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